adagrasib, azithromycin.Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.
albuterol and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
alfuzosin and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
amisulpride and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.
anagrelide and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin increases effects of antithrombin alfa by decreasing metabolism. Avoid or Use Alternate Drug.
azithromycin increases effects of antithrombin III by decreasing metabolism. Avoid or Use Alternate Drug.
azithromycin increases effects of argatroban by decreasing metabolism. Avoid or Use Alternate Drug.
aripiprazole and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
arsenic trioxide and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
artemether and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
atomoxetine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin decreases effects of BCG vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.
azithromycin increases effects of bemiparin by decreasing metabolism. Avoid or Use Alternate Drug.
azithromycin increases effects of bivalirudin by decreasing metabolism. Avoid or Use Alternate Drug.
buprenorphine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine buccal and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine subdermal implant and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine transdermal and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine, long-acting injection and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
ceritinib and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin, cholera vaccine. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Avoid coadministration of cholera vaccine with systemic antibiotics since these agents may be active against the vaccine strain. Do not administer cholera vaccine to patients who have received oral or parenteral antibiotics within 14 days prior to vaccination.
azithromycin increases toxicity of cisapride by QTc interval. Avoid or Use Alternate Drug.
clozapine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
cobicistat, azithromycin.Either increases levels of the other by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Consider alternative antibiotics with concomitant use of cobicistat coadministered with atazanavir or darunavir. .
azithromycin will increase the level or effect of colchicine by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Avoid use of colchicine with P-gp inhibitors. If coadministration is necessary, decrease colchicine dose or frequency as recommended in prescribing information. Use of any colchicine product in conjunction with P-gp inhibitors is contraindicated in patients with renal or hepatic impairment.
azithromycin increases effects of dalteparin by decreasing metabolism. Avoid or Use Alternate Drug.
desflurane and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin will increase the level or effect of digoxin by altering intestinal flora. Applies only to oral form of both agents. Avoid or Use Alternate Drug.
dofetilide increases toxicity of azithromycin by QTc interval. Avoid or Use Alternate Drug.
donepezil and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin and dronedarone both increase QTc interval. Contraindicated. Concomitant use of azithromycin and dronedarone may increase the risk of QT prolongation, cardiac arrhythmias.
efavirenz and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
eliglustat and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin increases effects of enoxaparin by decreasing metabolism. Avoid or Use Alternate Drug.
escitalopram increases toxicity of azithromycin by QTc interval. Avoid or Use Alternate Drug.
fexinidazole and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.
fingolimod and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin increases effects of fondaparinux by decreasing metabolism. Avoid or Use Alternate Drug.
gilteritinib and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin and givinostat both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid coadministration, obtain ECGs when initiating, during concomitant use, and as clinically indicated. Withhold if QTc interval >500 ms or a change from baseline >60 ms.
azithromycin and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.
granisetron and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin increases effects of heparin by decreasing metabolism. Avoid or Use Alternate Drug.
hydroxychloroquine sulfate and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
inotuzumab and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.
isoflurane and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
lefamulin and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
lithium and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
macimorelin and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.
azithromycin decreases effects of microbiota oral by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Microbiota oral contains bacterial spores. Antibacterial agents may decrease efficacy if coadministered. Complete antibiotic regimens 2-4 days before initiating microbiota oral. .
mirtazapine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.
oxaliplatin and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.
azithromycin increases effects of phenindione by decreasing metabolism. Avoid or Use Alternate Drug.
azithromycin increases levels of pomalidomide by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.
primaquine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin increases effects of protamine by decreasing metabolism. Avoid or Use Alternate Drug.
azithromycin will increase the level or effect of repotrectinib by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.
ribociclib increases toxicity of azithromycin by QTc interval. Avoid or Use Alternate Drug.
azithromycin will increase the level or effect of rimegepant by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.
azithromycin will increase the level or effect of riociguat by decreasing metabolism. Avoid or Use Alternate Drug. Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with strong CYP inhibitors may require a decreased initial dose of 0.5 mg PO TID; monitor for signs of hypotension and reduce dose if needed
sevoflurane and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
siponimod and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
tacrolimus and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.
azithromycin will increase the level or effect of topotecan by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Product labeling for PO topotecan recommends avoiding concomitant use of P-gp inhibitors; the interaction with IV topotecan may be less severe but is still likely of clinical significance
azithromycin increases levels of toremifene by decreasing metabolism. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.
azithromycin decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.
azithromycin increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.
azithromycin, vandetanib.Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.
vemurafenib and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended.
azithromycin will increase the level or effect of venetoclax by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. If a P-gp inhibitor must be used, reduce the venetoclax dose by at least 50%. Monitor more closely for signs of venetoclax toxicities.
azithromycin increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.
azithromycin increases levels of afatinib by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Reduce afatinib daily dose by 10 mg if not tolerated when coadministered with P-gp inhibitors.
azithromycin and alfuzosin both increase QTc interval. Use Caution/Monitor.
aluminum hydroxide decreases levels of azithromycin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
azithromycin will increase the level or effect of amiodarone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
amitriptyline and azithromycin both increase QTc interval. Use Caution/Monitor.
amoxapine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of apomorphine by QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of arformoterol by QTc interval. Use Caution/Monitor.
azithromycin and artemether/lumefantrine both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of asenapine by QTc interval. Use Caution/Monitor.
asenapine transdermal and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. If this combination is used, closely monitor for evidence of atorvastatin toxicity (eg, muscle aches or pains, renal dysfunction).
azithromycin will decrease the level or effect of balsalazide by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
azithromycin will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Modify Therapy/Monitor Closely.
azithromycin and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closely
azithromycin increases levels of berotralstat by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin increases levels of betrixaban by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Decrease betrixaban dose to 80 mg PO once, then 40 mg PO qDay if coadministered with a P-gp inhibitor.
azithromycin will decrease the level or effect of biotin by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
calcium carbonate decreases levels of azithromycin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
azithromycin decreases effects of cefdinir by pharmacodynamic antagonism. Use Caution/Monitor. bacteriostatic agents may inhibit the effects of bactericidal agents.
azithromycin decreases effects of cefditoren by pharmacodynamic antagonism. Use Caution/Monitor. bacteriostatic agents may inhibit the effects of bactericidal agents.
azithromycin decreases effects of cefoxitin by pharmacodynamic antagonism. Use Caution/Monitor. bacteriostatic agents may inhibit the effects of bactericidal agents.
azithromycin decreases effects of cefpodoxime by pharmacodynamic antagonism. Use Caution/Monitor. bacteriostatic agents may inhibit the effects of bactericidal agents.
azithromycin decreases effects of cefuroxime by pharmacodynamic antagonism. Use Caution/Monitor. bacteriostatic agents may inhibit the effects of bactericidal agents.
azithromycin increases levels of ceritinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin will increase the level or effect of cetirizine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin increases toxicity of chloroquine by QTc interval. Modify Therapy/Monitor Closely.chloroquine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor.
chlorpromazine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of ciprofloxacin by QTc interval. Use Caution/Monitor.
azithromycin and citalopram both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.
azithromycin and clarithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of clofazimine by QTc interval. Modify Therapy/Monitor Closely.
clomipramine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin will decrease the level or effect of conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Modify Therapy/Monitor Closely.
crizotinib and azithromycin both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.azithromycin increases toxicity of crizotinib by QTc interval. Use Caution/Monitor.
azithromycin will increase the level or effect of cyclosporine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin will increase the level or effect of dabigatran by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Atrial fibrillation: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <30 mL/min. DVT/PE treatment: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <50 mL/min
desipramine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of deutetrabenazine by QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).
dichlorphenamide and azithromycin both decrease serum potassium. Use Caution/Monitor.
azithromycin will decrease the level or effect of dienogest/estradiol valerate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor. An alternate or additional form of birth control may be advisable during concomitant use.
azithromycin and disopyramide both increase QTc interval. Modify Therapy/Monitor Closely.
azithromycin and dofetilide both increase QTc interval. Use Caution/Monitor.
doxepin and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin and droperidol both increase QTc interval. Use Caution/Monitor.
azithromycin will increase the level or effect of duvelisib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin will increase the level or effect of edoxaban by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Dose adjustment may be required with strong P-gp inhibitors. DVT/PE treatment: Decrease dose to 30 mg PO once daily. NVAF: No dose reduction recommended
azithromycin increases toxicity of encorafenib by QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of entrectinib by QTc interval. Use Caution/Monitor.
epinephrine and azithromycin both increase QTc interval. Use Caution/Monitor.
epinephrine racemic and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin and erythromycin base both increase QTc interval. Use Caution/Monitor.azithromycin will increase the level or effect of erythromycin base by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin and erythromycin ethylsuccinate both increase QTc interval. Use Caution/Monitor.azithromycin will increase the level or effect of erythromycin ethylsuccinate by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin and erythromycin lactobionate both increase QTc interval. Use Caution/Monitor.azithromycin will increase the level or effect of erythromycin lactobionate by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin and erythromycin stearate both increase QTc interval. Use Caution/Monitor.azithromycin will increase the level or effect of erythromycin stearate by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin increases toxicity of escitalopram by QTc interval. Use Caution/Monitor.
azithromycin will decrease the level or effect of estradiol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Modify Therapy/Monitor Closely.
azithromycin will decrease the level or effect of estrogens conjugated synthetic by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Modify Therapy/Monitor Closely.
azithromycin will decrease the level or effect of estropipate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Modify Therapy/Monitor Closely.
ezogabine, azithromycin.Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.
azithromycin and fluconazole both increase QTc interval. Use Caution/Monitor.
fluphenazine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin and formoterol both increase QTc interval. Use Caution/Monitor.
azithromycin and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.
gadobenate and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of gemifloxacin by QTc interval. Use Caution/Monitor.
azithromycin and gemtuzumab both increase QTc interval. Use Caution/Monitor.
gepirone and azithromycin both increase QTc interval. Modify Therapy/Monitor Closely.
azithromycin will increase the level or effect of glecaprevir/pibrentasvir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
goserelin increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
azithromycin and haloperidol both increase QTc interval. Use Caution/Monitor.
histrelin increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
hydroxyzine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
azithromycin and ibutilide both increase QTc interval. Modify Therapy/Monitor Closely.
imipramine and azithromycin both increase QTc interval. Use Caution/Monitor.
indacaterol, inhaled, azithromycin. QTc interval. Use Caution/Monitor. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias.
azithromycin and indapamide both increase QTc interval. Modify Therapy/Monitor Closely.
azithromycin will increase the level or effect of indinavir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin increases toxicity of isradipine by QTc interval. Use Caution/Monitor.
azithromycin and itraconazole both increase QTc interval. Use Caution/Monitor.
azithromycin and ketoconazole both increase QTc interval. Use Caution/Monitor.
azithromycin and lenvatinib both increase QTc interval. Use Caution/Monitor. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs.
leuprolide increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
levoketoconazole will increase the level or effect of azithromycin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.azithromycin and levoketoconazole both increase QTc interval. Use Caution/Monitor.
lofepramine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of lofexidine by QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of lopinavir by QTc interval. Use Caution/Monitor.
azithromycin will increase the level or effect of loratadine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin will increase the level or effect of lovastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
azithromycin and lumefantrine both increase QTc interval. Use Caution/Monitor.
maprotiline and azithromycin both increase QTc interval. Use Caution/Monitor.
mavorixafor and azithromycin both increase QTc interval. Modify Therapy/Monitor Closely. Mavorixafor causes concentration-dependent QTc prolongation. Monitor QTc during treatment in patients with risk factors for QTc prolongation (eg, coadministered medications that increase mavorixafor exposure or other drugs with a high risk to prolong the QTc interval). Mavorixafor dose reduction or discontinuation may be required.
azithromycin will decrease the level or effect of mestranol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Modify Therapy/Monitor Closely.
mifepristone, azithromycin. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.
azithromycin and moxifloxacin both increase QTc interval. Use Caution/Monitor.
azithromycin increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Monitor naldemedine for potential adverse effects if coadministered with P-gp inhibitors.
azithromycin and nilotinib both increase QTc interval. Use Caution/Monitor.
azithromycin increases levels of nintedanib by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. If nintedanib adverse effects occur, management may require interruption, dose reduction, or discontinuation of therapy .
nortriptyline and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin and octreotide both increase QTc interval. Use Caution/Monitor.
azithromycin and octreotide (Antidote) both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of olanzapine by QTc interval. Use Caution/Monitor.
azithromycin and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias
osilodrostat and azithromycin both increase QTc interval. Use Caution/Monitor.
osimertinib and azithromycin both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.
oxaliplatin will increase the level or effect of azithromycin by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.
ozanimod and azithromycin both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.
azithromycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
azithromycin and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.
azithromycin and pentamidine both increase QTc interval. Modify Therapy/Monitor Closely.
perphenazine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin and pimozide both increase QTc interval. Modify Therapy/Monitor Closely.
azithromycin decreases effects of piperacillin by pharmacodynamic antagonism. Use Caution/Monitor. bacteriostatic agents may inhibit the effects of bactericidal agents.
azithromycin and procainamide both increase QTc interval. Modify Therapy/Monitor Closely.
prochlorperazine and azithromycin both increase QTc interval. Use Caution/Monitor.
promazine and azithromycin both increase QTc interval. Use Caution/Monitor.
promethazine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of propafenone by QTc interval. Use Caution/Monitor.
protriptyline and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin will decrease the level or effect of pyridoxine by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
azithromycin will decrease the level or effect of pyridoxine (Antidote) by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
quetiapine, azithromycin.Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT.
quinidine and azithromycin both increase QTc interval. Modify Therapy/Monitor Closely.
azithromycin and quinine both increase QTc interval. Use Caution/Monitor.
quizartinib, azithromycin.Either increases effects of the other by QTc interval. Modify Therapy/Monitor Closely. Monitor patients more frequently with ECG if coadministered with QT prolonging drugs.
azithromycin will increase the level or effect of ranolazine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin increases toxicity of ribociclib by QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of rifabutin by decreasing metabolism. Use Caution/Monitor.
azithromycin will increase the level or effect of rifampin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin increases levels of rifaximin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
rilpivirine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes.
azithromycin will increase the level or effect of ritonavir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin increases levels of rivaroxaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Patients with renal impairment receiving rivaroxaban with drugs that are combined P-gp and weak or moderate CYP3A4 inhibitors may have significant increases in exposure compared with patients with normal renal function and no inhibitor use, since both pathways of rivaroxaban elimination are affected. Since these increases may increase bleeding risk, use rivaroxaban in this situation only if the potential benefit justifies the potential risk.
azithromycin and romidepsin both increase QTc interval. Use Caution/Monitor.azithromycin will increase the level or effect of romidepsin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
selpercatinib increases toxicity of azithromycin by QTc interval. Use Caution/Monitor.
azithromycin will increase the level or effect of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
sodium bicarbonate decreases levels of azithromycin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
sodium citrate/citric acid decreases levels of azithromycin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
azithromycin decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug.
sorafenib and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin and sotalol both increase QTc interval. Modify Therapy/Monitor Closely.
azithromycin will increase the level or effect of tacrolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
azithromycin will increase the level or effect of talazoparib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Talazoparib is a P-glycoprotein (P-gp) substrate; coadministration with P-gp inhibitors may increase talazoparib systemic exposure.
azithromycin will decrease the level or effect of thiamine by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
thioridazine and azithromycin both increase QTc interval. Use Caution/Monitor.
tobramycin inhaled and azithromycin both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicity
azithromycin will increase the level or effect of tolvaptan by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone and azithromycin both increase QTc interval. Use Caution/Monitor.
trifluoperazine and azithromycin both increase QTc interval. Use Caution/Monitor.
trimipramine and azithromycin both increase QTc interval. Use Caution/Monitor.
triptorelin increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
valbenazine and azithromycin both increase QTc interval. Use Caution/Monitor.
azithromycin will increase the level or effect of verapamil by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
voclosporin, azithromycin.Either increases effects of the other by QTc interval. Use Caution/Monitor.
azithromycin increases toxicity of warfarin by anticoagulation. Use Caution/Monitor. Postmarketing reports have suggested that concomitant administration of azithromycin may potentiate effects of oral warfarin but the interaction does not appear to alter prothrombin time.
azithromycin and ziprasidone both increase QTc interval. Use Caution/Monitor.
azithromycin decreases effects of amoxicillin by pharmacodynamic antagonism. Minor/Significance Unknown.
azithromycin decreases effects of ampicillin by pharmacodynamic antagonism. Minor/Significance Unknown.
azithromycin increases toxicity of clozapine by unspecified interaction mechanism. Minor/Significance Unknown. Enhanced CNS toxicity.
azithromycin and dasatinib both increase QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of degarelix by QTc interval. Minor/Significance Unknown.
azithromycin decreases effects of dicloxacillin by pharmacodynamic antagonism. Minor/Significance Unknown.
azithromycin and dolasetron both increase QTc interval. Minor/Significance Unknown.
azithromycin increases levels of ergotamine by unknown mechanism. Minor/Significance Unknown.
azithromycin increases toxicity of eribulin by QTc interval. Minor/Significance Unknown.
azithromycin and flecainide both increase QTc interval. Minor/Significance Unknown.
azithromycin and fluoxetine both increase QTc interval. Minor/Significance Unknown.
azithromycin and foscarnet both increase QTc interval. Minor/Significance Unknown.
azithromycin and iloperidone both increase QTc interval. Minor/Significance Unknown.
azithromycin and lapatinib both increase QTc interval. Minor/Significance Unknown.
azithromycin and levofloxacin both increase QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of mefloquine by QTc interval. Minor/Significance Unknown.
azithromycin and methadone both increase QTc interval. Minor/Significance Unknown.
azithromycin decreases effects of nafcillin by pharmacodynamic antagonism. Minor/Significance Unknown. bacteriostatic antibiotics may interfere with the bactericidal actions of penicillins.
azithromycin and ofloxacin both increase QTc interval. Minor/Significance Unknown.
azithromycin decreases effects of oxacillin by pharmacodynamic antagonism. Minor/Significance Unknown. bacteriostatic antibiotics may interfere with the bactericidal actions of penicillins.
azithromycin and paliperidone both increase QTc interval. Minor/Significance Unknown.
azithromycin and paroxetine both increase QTc interval. Minor/Significance Unknown.
azithromycin and pazopanib both increase QTc interval. Minor/Significance Unknown.
azithromycin decreases effects of penicillin G aqueous by pharmacodynamic antagonism. Minor/Significance Unknown.
azithromycin decreases effects of penicillin VK by pharmacodynamic antagonism. Minor/Significance Unknown.
azithromycin increases toxicity of pimavanserin by QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of pitolisant by QTc interval. Minor/Significance Unknown.
azithromycin and posaconazole both increase QTc interval. Minor/Significance Unknown.
azithromycin and ranolazine both increase QTc interval. Minor/Significance Unknown.
azithromycin and risperidone both increase QTc interval. Minor/Significance Unknown.
azithromycin will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
azithromycin will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
azithromycin increases toxicity of sertraline by QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of solifenacin by QTc interval. Minor/Significance Unknown.
azithromycin and sulfamethoxazole both increase QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of sunitinib by QTc interval. Minor/Significance Unknown.
azithromycin and telavancin both increase QTc interval. Minor/Significance Unknown.
azithromycin decreases effects of temocillin by pharmacodynamic antagonism. Minor/Significance Unknown.
azithromycin increases toxicity of tetrabenazine by QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of thiothixene by QTc interval. Minor/Significance Unknown.
azithromycin and trimethoprim both increase QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of trimipramine by QTc interval. Minor/Significance Unknown.
azithromycin and tropisetron both increase QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of vardenafil by QTc interval. Minor/Significance Unknown.
azithromycin and venlafaxine both increase QTc interval. Minor/Significance Unknown.
azithromycin and voriconazole both increase QTc interval. Minor/Significance Unknown.
azithromycin increases toxicity of vorinostat by QTc interval. Minor/Significance Unknown.